Structural features of CHD1 and visualization of its condensate formation (IMAGE)

Nano Life Science Institute (NanoLSI), Kanazawa University

Structural features of CHD1 and visualization of its condensate formation

Caption

Single-molecule HS-AFM imaging revealed that CHD1 contains flexible intrinsically disordered regions (IDRs) at its N- and C-termini and in the central region (A). The cancer-associated E1321 frameshift mutation results in the loss of the C-terminal IDR (B). In the nucleus, CHD1 forms liquid–liquid phase–separated condensates via its IDRs (C). HR-AFM imaging of purified CHD1 showed that these condensates adopt soft, disk-like structures (D).

Credit

Modified from Tsukamoto et al., Nature Communications (2025), CC BY 4.0.

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