Dlc1 knockout affects cardiac progenitor differentiation via the Wnt signaling pathway. (IMAGE)
Caption
(A) KEGG analysis highlights pathways at day 3. (B, C) Gene Set Enrichment Analysis (GSEA) revealed the differentially expressed genes related to Wnt signaling pathways and Ctnnb1 target genes at day 3. NES, normalized enrichment score. (D) The heatmap represents genes related to the Wnt signaling pathway in the control embryonic bodies (EBs) versus Dlc1-knockout EBs at day 3, day 5, and day 9. (E) Quantification of EB size under indicating treatment. n > 90. (F) Real-time PCR analysis of marker expression at day 3 under indicating treatment. n = 3. Data were shown as mean ± standard deviation; *P < 0.05 and **P < 0.01; ns, not significant.
Credit
Wei Wei, Xuechao Jiang, Wenxiang Shi, Junmei Zhou, Rang Xu
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