The influence of various therapeutic drugs on clinical symptoms. (IMAGE)
Caption
(A) Changes in body weight in mice after DSS. (B) The change in DAI score after DSS. Data are means±SEM, n=6 in DSS group and in the other group. (C) Changes in body weight of mice after drug treatment. (D) Changes in DAI score in each group of mice after treatment. (E) Changes in spleen index in mice after drug treatment. (F) Length of colon between the ileocaecal junction and the proximal rectum. (G) Representative H&E staining (100x) images of colonic tissues from the CT, DSS, AMPs, 5-ASA and CIP groups. (H) MPO content in colon tissues of each treatment group. Data are presented as mean±SD (n=6); significant differences were indicated by *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. AMP, antimicrobial peptide; 5-ASA, 5-aminosalicylic acid; CIP, ciprofloxacin; CT, blank control; DAI, Disease Activity Index; DSS, dextran sulfate sodium; MPO, myeloperoxidase; ns, not significant.
Credit
By Hui Miao, Ziwei Wang, Pengfei Cui, et al.
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