Resident macrophages exert critical effects on intense light attenuating cardiac inflammation (IMAGE)
Caption
(A) The split t-distributed stochastic neighbor embedding (t-SNE) map of four macrophage subsets in the RVes. (B) The cell proportions of macrophage subsets in the RVes. (C) The heatmap of the top DEGs based on group and macrophage subsets. (D) The top DEGs down-regulated in HI versus HR and up-regulated in HR versus PR of Res_Macro. (E) GO enrichment analysis of the DEGs in (D). n = 3 per group. DEG, differentially expressed gene; RVes, right ventricle; HR, hypoxia and room light; PR, physiological normoxia and room light; HI, intense light and hypoxia; SS_Macro, steady-state macrophage; Mo_Macro, monocyte-derived macrophage; Res_Macro, resident macrophage; Pro_Macro, proliferating macrophage
Credit
Dingyuan Tian, Yingzi Pan, Xiaoyue Lai, Xinyu Bao, Pan Zheng, Yan Tan, Chun Liu, Ziyang Wang, Qingyuan Yang, Yang Liu, Xiaoqin Wan, Zhihui Zhang, Fang Deng
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License
CC BY-NC-ND