The levels of RV hypertrophy and RV dysfunction in mice subjected to normoxia or hypoxia with room light and hypoxia with intense light (IMAGE)
Caption
(A–D) The s' and TAPSE levels of mice in each group and the statistical analyses. (E, F) The AT/ET levels of mice in each group and the statistical analyses. (G) The levels of RVSP in mice of each group. (H) The levels of TAPSE/RVSP in mice of each group. (I, J) The RVFW and RVAW levels and the statistical analyses. (K) The levels of RV hypertrophy (Fulton index). (L) The level of hydroxyproline in the RVes. (M, N) The levels of Col1A in the RVes. n = 8 per group. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.001; ns, no significant. The error bars represent the standard error of the mean. RVe, right ventricle; RV, right ventricular; HR, hypoxia and room light; PR, physiological normoxia and room light; HI, intense light and hypoxia; s', RV peak systolic myocardial velocity; TAPSE, Tricuspid annular plane systolic excursion; AT/ET, pulmonary artery acceleration time/pulmonary artery ejection time; RVSP, RV systolic pressure; RVFW, RV free wall thickness; RVDD, RV end-diastolic inner dimension; Col1A, collagen type I alpha 1.
Credit
Dingyuan Tian, Yingzi Pan, Xiaoyue Lai, Xinyu Bao, Pan Zheng, Yan Tan, Chun Liu, Ziyang Wang, Qingyuan Yang, Yang Liu, Xiaoqin Wan, Zhihui Zhang, Fang Deng
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