Ube2d1+/− mice in the collagen antibody-induced arthritis (CAIA) model (IMAGE)
Caption
(A) Time-course plot showing arthritis scores over 14 days: Ube2d1+/− CAIA mice and WT CAIA mice (∗∗∗∗p < 0.0001). (B) Representative images of hind paw swelling in different groups: Ube2d1+/− control, Ube2d1+/− CAIA, WT control, and WT CAIA. (C) Quantitative micro-CT analysis of bone parameters in Ube2d1+/− and WT mice with or without CAIA induction. Bone mineral density (BMD, left) and bone volume/tissue volume ratio (BV/TV, right) were measured in the hind paw joints (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001). (D) Representative micro-CT 3D reconstructions of ankle joints: Ube2d1+/− control, Ube2d1+/− CAIA, WT control, and WT CAIA. (E) Representative multiplex immunofluorescence staining images of joint tissues from four experimental groups: Ube2d1+/− control, Ube2d1+/− CAIA, WT control, and WT CAIA. (F) Quantification of CXCL10 expression in joint tissues (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001). (G) The expression levels of cytokines related to sJIA in Ube2d1+/− control, Ube2d1+/− CAIA, WT control, and WT CAIA (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001). (H) The expression levels of NOD-like receptor signaling (NLR) pathway proteins related to sJIA in Ube2d1+/− control, Ube2d1+/− CAIA, WT control, and WT CAIA (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, and ∗∗∗∗p < 0.0001)
Credit
Qiang Luo, Jun Yang, Haiguo Yu, Han Hao, Xinglin Wu, Xiwen Luo, Mingsheng Ma, Xi Yang, Zhiyong Zhang, Yunfei An, Xiaodong Zhao, Hongmei Song, Xuemei Tang
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CC BY-NC-ND