PLXNC1 is elevated and predicts worse outcomes in colorectal cancer (IMAGE)
Caption
(A) PLXNC1 expression in different cancers and normal tissues in the Oncomine database. The red and blue denote up-regulation and down-regulation of PLXNC1 in the tumor tissues, respectively. (B) The meta-analyses of PLXNC1 over-expression cohorts or under-expression cohorts in colorectal cancer. (C) The protein levels of PLXNC1 in colon cancer samples and matched normal samples from the Clinical Proteomic Tumor Analysis Consortium. (D) Representative immunohistochemical staining for PLXNC1 based on the tissue microarray (TMA) of colon cancer samples and matched normal samples. Scale bars = 200 μm. (E) Quantitative analysis of PLXNC1 protein expression scores from the immunohistochemical staining of the tissue microarray. (F) Kaplan–Meier curves for overall survival (OS) between the high- and low-PLXNC1 expressing CRC patients from the TCGA and different GEO data sets.
Credit
Weiqi Wang, Mingxuan Zhou, Tiegang Li, Wenqiang Gan, Silin Lv, Zheng Yan, Yufang Hou, Zifan Zeng, Liu Yang, Fang Zhang, Wenyi Zhao, Min Yang
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