The up-regulation of ATOX1 attenuates oxidative stress, apoptosis, and neuroinflammation in BV2 cells. (IMAGE)
Caption
(A–C) Expression levels of antioxidants, superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA), were measured in comparison to NC-BV2. (D–I) Western blot analysis was used to measure Bcl2, BAX, and cleaved caspase 3 expression in lentivirus-treated BV2 microglia with or without Aβ1-42. Quantifications of protein levels are shown in E, G, I. (M, N) The IL-1β and IL-6 levels in lentivirus-treated BV2 microglia with or without Aβ1-42 were measured by ELISA. nsP > 0.05, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001; data were reported as mean ± standard error of the mean; one-way ANOVA analysis followed by Tukey's multiple comparison test.
Credit
Fuxin Zhong, Jiani Wu, Zhangjing Deng, Wuhan Yu, Jiaqi Song, Yingxi Chen, Weihua Yu, Yang Lü
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