miR-451a abolishes ADAR1p110-mediated HCC metastasis. (IMAGE)
Caption
(A, B) Representative images and quantification of migration induced by miR-451a overexpression (A) (n = 18) or knockdown (B) (n = 10) cells. (C, D) Representative images and quantification of wound healing induced by miR-451a overexpression (C) (n = 12) or knockdown (D) (n = 5) cells. (E) Representative images and quantification of migration induced by the indicated CRL8024 cells (n = 15). (F) Representative images and quantification of wound healing induced by indicated CRL8024 cells (n = 6). (G–I) Representative image (G) and quantification of the metastasis rates (H) and tumor numbers (I) of the spleen injection liver metastasis mouse model. The data are presented as mean ± SD. P values were computed using the unpaired Student's t-test (A–D), one-way ANOVA test (E, F), Exact binomial test (H), and Brown–Forsythe test (I). ns: not significant. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001.
Credit
Liangzhan Sun, Hui Yang, Pengchao Hu, Jingyi Zheng, Yuyang Du, Shasha Wu, Han Gao, Hao Luo, Yanchen Wang, Fenfen Wang, Jingsong Yan, Xin-Yuan Guan , Yan Li
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CC BY-NC-ND