CXCR4 is highly expressed in aldosterone-producing lesions. (IMAGE)
Caption
(A) Immunohistochemical staining and corresponding average optical density values of CXCR4 and CYP11B2 in the adrenal samples of NFA (n = 20), KCNJ5-mutated UPA (n = 30), ATP1A1-mutated UPA (n = 7), ATP2B3-mutated UPA (n = 3), CACNA1D-mutated UPA (n = 3), and UPA with no mutations (n = 3). Scale bars, 2 mm or 50 μm. (B) Immunohistochemical staining of CXCR4 and CYP11B2 in MAPM and average optical density values of CXCR4 and CYP11B2 in the adrenal samples of NFA (n = 20), APA (n = 34), APN (n = 12), and MAPM (n = 10). Scale bars, 1 mm, 100 μm, 50 μm. The data were presented as mean ± standard deviation. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. NFA, non-functional adenoma; UPA, unilateral primary aldosteronism; APA, aldosterone-producing adenoma; APN, aldosterone-producing nodule; MAPM, multiple aldosterone-producing micronodule.
Credit
Jiang Chen, Shumin Yang, Xinyue Yang, Jiayu Li, Yifan He, Chuan Peng, Wei Zhang, Yi Yang, Junlong Li,Hongji Li, Furong He, Yong Xu, Wei Huang, Jinbo Hu, Qifu Li, Linqiang Ma
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