CXCR4 inhibits aldosterone synthesis via up-regulation of ID3. (IMAGE)
Caption
(A) Western blotting analysis and quantification of indicated proteins in H295R cells with ID3 overexpression (n = 6). (B) CYP11B2 mRNA expression in H295R cells with ID3 overexpression (n = 3). (C) Steroid hormone levels (ng per mg protein) in the supernatant of H295R cells after ID3 overexpression, including progesterone, 11-deoxycorticosterone, 18-hydroxycorticosterone, and aldosterone (n = 3). (D) Western blotting analysis and quantification of indicated proteins in H295R cells overexpressing CXCR4 with or without ID3 knockdown (n = 3). The data were presented as mean ± standard deviation. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.
Credit
Jiang Chen, Shumin Yang, Xinyue Yang, Jiayu Li, Yifan He, Chuan Peng, Wei Zhang, Yi Yang, Junlong Li,Hongji Li, Furong He, Yong Xu, Wei Huang, Jinbo Hu, Qifu Li, Linqiang Ma
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND