Knockdown of CXCR4 promotes aldosterone synthesis in H295R cells. (IMAGE)
Caption
(A) Steroid hormone levels (ng per mg protein) in the supernatant of H295R cells after CXCR4 knockdown, including progesterone, 11-deoxycorticosterone, corticosterone, 18-hydroxycorticosterone, and aldosterone (n = 6). (B) Western blotting analysis and quantification of indicated proteins in H295R cells with CXCR4 knockdown (n = 3). (C) CYP11B2 and CXCR4 mRNA expression in H295R cells with CXCR4 knockdown (n = 3). The data were presented as mean ± standard deviation. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.
Credit
Jiang Chen, Shumin Yang, Xinyue Yang, Jiayu Li, Yifan He, Chuan Peng, Wei Zhang, Yi Yang, Junlong Li,Hongji Li, Furong He, Yong Xu, Wei Huang, Jinbo Hu, Qifu Li, Linqiang Ma
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND