PTHrP promotes BMP2-induced chondrogenic differentiation of mesenchymal stem cells (MSCs) in vivo (IMAGE)
Caption
(A) PTHrP potentiated BMP2-induced chondrogenic and inhibited hypertrophic differentiation of MSCs in 4-week samples. Hematoxylin–eosin staining (right two panels) and Safranin-O-fast blue staining (left two panels). (B) PTHrP potentiated BMP2-induced chondrogenic and inhibited hypertrophic differentiation of MSCs in 8-week samples. Hematoxylin–eosin staining (right two panels) and Safranin-O-fast blue staining (left two panels). (C) Quantitative analysis of Safranin-O areas in 4-week samples (a) and 8-week samples (b). ##P < 0.01, ###P < 0.001, and ####P < 0.0001, compared with the control group. ∗P < 0.5, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001, compared with the indicated group. Scale bar: 500 μm in left panels and 100 μm in right panels.
Credit
Shengqiang Gao, Piao Zhao, Tingting Du, Yu Ye, Shengwen Cheng, Senrui Liu, Chengcheng Du, Tong-Chuan He, Wei Huang, Zhenglin Zhu, Wei Xu, Junyi Liao
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CC BY-NC-ND