PI3K–AKT signaling mediates BMP2-induced hypertrophic differentiation that is inhibited by PTHrP (IMAGE)
Caption
(A) PI3K–AKT inhibitor Wortmannin (Wor) suppresses BMP2-induced Runx2 expression and PI3K–AKT activation. WOR inhibited p-AKT, PI3KP85, and p-PI3KP85expression at the protein level (a), and quantitative analysis also showed these effects (b). ##P < 0.01, ###P < 0.001, and ####P < 0.0001, compared with the control group. ∗P < 0.5, ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001, compared with the indicated group. (B) PTHrP inhibited BMP2-induced hypertrophic differentiation of mesenchymal stem cells (MSCs) by activating PI3K–AKT signaling (graphical representation was contributed by Zhenglin Zhu on BioRender.com)
Credit
Shengqiang Gao, Piao Zhao, Tingting Du, Yu Ye, Shengwen Cheng, Senrui Liu, Chengcheng Du, Tong-Chuan He, Wei Huang, Zhenglin Zhu, Wei Xu, Junyi Liao
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CC BY-NC-ND