Integrated regulatory cross-talk shapes cGAS-STING output (IMAGE)

Science China Press

Integrated regulatory cross-talk shapes cGAS-STING output

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A network view of how AKT-mTOR, AMPK-ULK1, JNK-BAX, PERK-eIF2α, p53 and DNA-clearance pathways converge on the cGAS-STING signaling hub. Competing feedback loops determine whether signaling is amplified, restrained or redirected toward alternative cellular outcomes.

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