Examples of heterogeneity in variation in symptom severity (IMAGE)
Caption
Examples of heterogeneity in variation in symptom severity over two menstrual cycles. The two graphs in the left panel show the average cosine regression curve of the total DRSP score for all patients with PMDD and controls. In the right panel, there are six examples of cosine regression curves of patients with PMDD over two menstrual cycles for each PMDD symptom, and three examples of controls, based on individual cosine regression models. The cosine regression curves represent how the symptoms vary over the two menstrual cycles, with steeper curves representing a more marked increase/decrease between the symptomatic and the asymptomatic phase. A W-shaped curve indicates a premenstrual increase of symptom, while an M-shaped curve indicates a midcycle increase of symptom. The timescale is proportional and scaled differently in the follicular and luteal phases based on each individual’s cycle lengths of the two phases when setting ovulation to day -15, with 0 representing the first day of the first cycle, 1 representing the last day of the first cycle, and 2 representing the last day of the second cycle. The scores are predicted from the cosine regression models and do therefore not directly reflect the raw DRSP scores.
Credit
Erika Comasco and Ella Schleimann-Jensen
Usage Restrictions
Credit must be given to the creator.
License
CC BY