Variability and severity of premenstrual symptoms across the menstrual cycle in patients with PMDD and controls (IMAGE)
Caption
Variability and severity of premenstrual symptoms across the menstrual cycle in patients with PMDD and controls. Visualized are the estimated values of cosine amplitudes (x-axis) for patients with PMDD (n=90) and controls (n=44) yielded from the final multilevel cosine regression models for each individual symptom (y-axis). The cosine amplitudes correspond both to the timing and severity of symptoms across the menstrual cycle. Timing is indicated by the sign of the value, where positive values indicate a premenstrual increase of symptoms, negative values correspond to a mid-cycle increase of symptoms, and values of zero indicate no variation in symptomatology across the menstrual cycle. Severity is indicated by the magnitude of the cosine amplitude value, where larger/more negative values correspond to a higher severity of symptom premenstrually/mid-cycle, respectively. Each box represents 50% of the data, with the median line in bold. The whiskers extend to the minimum and maximum of the data, except for those with outliers which are represented by the dots. The violin plot illustrates the density distribution of the cosine amplitudes (i.e., a flatter curve indicates that the values are more spread along the values on the x-axis). The cosine regression models that the cosine amplitudes stem from are estimated using a proportional time variable that is scaled differently in the follicular and luteal phases depending on each individual’s length of each phase when setting ovulation to day -15.
Credit
Erika Comasco and Ella Schleimann-Jensen
Usage Restrictions
Credit must be given to the creator.
License
CC BY