レポーターアッセイによるCpG3メチル化の機能的解析 (IMAGE) Kumamoto University Caption A)CpG部位を人工的にメチル化させ蛍光標識したDNA鎖(レポーターコンストラクト)を神経系細胞株に導入して、発光蛋白質の活性を測定することにより転写活性化能を測定。 B)メチル化されると転写活性化能は失われ。 Credit Professor Kazuya Iwamoto Usage Restrictions <p>Adapted from figure 2 of <a href="https://academic.oup.com/schizophreniabulletin/advance-article/doi/10.1093/schbul/sbaa075/5859552">Ikegame, T. et al, 2020</a>. </p> <p>This image is made available under Oxford University Press <a href="https://academic.oup.com/journals/pages/access_purchase/rights_and_permissions/publication_rights">"Rights retained by ALL Oxford Journal authors"</a>. Any further distribution of this work must follow OUP's terms of reuse. </p> License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.