Photo 3 (IMAGE)

DGIST (Daegu Gyeongbuk Institute of Science and Technology)

Photo 3

Caption

(Left) Preparation for docking between R486 in the RDR region of simulated TMEM16A(ac) S673A and PI(4,5)P2 or PI(4)P, showing the initial orientation of the ion channel and PI(4,5)P2 before docking. (Upper Right) Autodock Vina was used in UCSF Chimera for docking of GIRK PI(4,5)P2 to the simulated structure (Lower Right) Docking of PI(4)P to the RDR region. None of the hydrogen bonds interacts with R486. The lowest energy level was -5.5 kcal/mol.

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PNAS

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