Callus Ossification Progresses after Most of the Realignment Has Occurred (IMAGE)
Caption
These are 3-D in vivo CT images of a fractured humerus at P5 (A), P9 (B), and P11 (C). (B' and C') 2-D in vivo CT images of the same bone at P9 and P11, respectively. Scale bar, 2 mm. Magnifications of the concave side of the fracture, demarcated by a red dashed box in (C'). The presence of chondrocytes (indicated by black arrows) is demonstrated by H&E staining (D) and by in situ hybridization for Col10a1 (E). The progression of the mineralization process from the convex toward the concave side is shown by the osteoblastic marker Bsp (F). Scale bar, 200 mm. (G) Scatter plot showing the angle between the two fragments of all fractured humeri (n = 13), as measured at P5 (blue diamond), during callus ossification (P11-P15, green X) and at P28 (red circle).
Credit
<i>Developmental Cell</i>, Rot </i>et al.</i>
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