Figure 2. A schematic model of oxidative stress-induced SAPK activation. (IMAGE)

The Institute of Medical Science, The University of Tokyo

Figure 2. A schematic model of oxidative stress-induced SAPK activation.

Caption

Both the MTK1 and ASK1 SAPKKKs are major mediators of oxidative stress-induced SAPK signaling. However, they have different time and dose response characteristics. While ASK1 rapidly and sensitively responds to oxidative stress, and induces early and transient activation of SAPKs, MTK1 is relatively less sensitive to oxidative stress and slowly activated. However, once MTK1 is activated, it can elicit prolonged SAPK activation to dictate cell fate decisions. GARD, GADD45-binding and redox-sensor domain.

Credit

©TAKEKAWA Mutsuhiro

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