Localization of SAP-1 on the Brush-Border Microvilli of Intestinal Epithelial Cells (IMAGE)

Kobe University

Localization of SAP-1 on the Brush-Border Microvilli of Intestinal Epithelial Cells

Caption

The extracellular domain of SAP-1 extends into the intestinal lumen and its active tyrosine phosphatase domain resides in the cytoplasm. SAP-1 is thought to inhibit the development of colitis by suppressing CEACAM20 functions. Similar to SAP-1, CEACAM20 is localized to the epithelial microvilli. PTP, protein tyrosine phosphatase.

Credit

2004- Kobe University. All Rights Reserved.

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.