(IMAGE)

Kobe University

Caption

The extracellular domain of SAP-1 extends into the intestinal lumen and its active tyrosine phosphatase domain resides in the cytoplasm. SAP-1 is thought to inhibit the development of colitis by suppressing CEACAM20 functions. Similar to SAP-1, CEACAM20 is localized to the epithelial microvilli. PTP, protein tyrosine phosphatase.

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2004- Kobe University. All Rights Reserved.

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