Molecular mechanisms of increased peritoneal dissemination of cancer (IMAGE)

Kumamoto University

Molecular mechanisms of increased peritoneal dissemination of cancer

Caption

In gastric cancer peritoneal dissemination, CAFs in ascites undergo cellular senescence due to the surrounding inflammatory environment. The senescent CAFs continue to secrete senescence-associated proteins that promote cancer progression by activating genes that form senescence-associated proteins (SASP genes), resulting in increased peritoneal dissemination of cancer.

Credit

Dr. Takatsugu Ishimoto

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<p>Adapted from the graphical abstract of <a href="https://www.sciencedirect.com/science/article/pii/S2211124721000929">Yasuda T. et.al., Cell Reports, 2021</a>. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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