MES+HS ameliorates glomerular and tubular damage in ADR-induced NS and reduces the number of podocytes (IMAGE)

Kumamoto University

MES+HS ameliorates glomerular and tubular damage in ADR-induced NS and reduces the number of podocytes

Caption

(Top row) Sclerotic lesions in the glomeruli, which play a role in the urinary filtration function of the kidney, were observed in the pathological model. However, in the MES+HS treatment group, sclerotic lesions due to ADR were suppressed.

(Middle row) An increase in the number of protein casts, reflecting tubular dysfunction, was observed In the pathological model but were reduced in the MES+HS treatment group.

(Bottom row) Immunostaining revealed reduced numbers of glomerular epithelial cells (podocytes), the cells highly affected by focal segmental glomerulosclerosis, one of the major causes of NS. Treatment with MES+HS inhibited the loss of podocytes.

Credit

Professor Hirofumi Kai

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<p>Adapted from Fig. 2 of <a href="https://www.nature.com/articles/s41598-020-75761-8">Teramoto, K. et.al., Scientific Reports, 2020</a>. It has been modified in part from the original. </p> <p>This image is made available under the terms of <a href="https://creativecommons.org/licenses/by/4.0/">CC by 4.0</a>. Any further distribution of this work must follow the terms of this license. </p>

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