3 Positions of Mutations in the 4-Protein Complex Called DNMT3A (IMAGE)

University of California - Santa Barbara

3 Positions of Mutations in the 4-Protein Complex Called DNMT3A

Caption

This image, created using X-ray crystallography, shows three positions of mutations in the four-protein complex called DNMT3A. The mutations are disruptions of DNMT3A and are circled in black. The mutations appear different from each other because the proteins are configured differently at each interface. In patients with acute myeloid leukemia, DNMT3A is mutated.

Credit

Norbert Reich, UCSB

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