Four-Protein Complex Called DNMT3A Shown in its Normal Configuration (IMAGE)

University of California - Santa Barbara

Four-Protein Complex Called DNMT3A Shown in its Normal Configuration

Caption

In this artist's conception, the four-protein complex called DNMT3A is shown in its normal configuration (top left). The complex reads or "tags" the cell's DNA. In the upper right side of the image, several of these tags are shown on top of the double helix of DNA. The tags control which genes in a cell get turned on and off. In the bottom left image, the complex of four proteins is disrupted. This disruption is caused by the mutation found in patients with acute myeloid leukemia. In the right side of the bottom image, the protein leaves only one tag on the DNA and then moves on.

Credit

Norbert Reich, UCSB

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