Figure 3. (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

Figure 3.

Caption

In normal cell (left), the cytoplasmic flux over several hours increases PER abundance in the perinucleus (pink region in Figure 2) compared with the peripheral cytoplasm (cyan region in Figure 2) (i). This induces a sharp switch-like hyperphosphorylation in the perinucleus due to the cooperativity (ii), followed by synchronous nuclear entry within a narrow time window (iii). When a cell is overcrowded (right), the cytoplasmic flux is hindered, and thus PER does not accumulate in the same gradient as in the normal cell (i). This disables the sharp switch-like PER hyperphosphorylation and nuclear entry (ii and iii).

Credit

Professor Jae Kyoung Kim, KAIST

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