Figure 2. (IMAGE)

The Korea Advanced Institute of Science and Technology (KAIST)

Figure 2.

Caption

Spatial Stochastic model of the circadian clock. After Per mRNA, M, is translated to protein, R, in the cytoplasm (i), PER transits toward the perinucleus, past obstacles while being hypophosphorylated (ii; gray circle). The accumulated PER in the perinucleus is hyperphosphorylated in a cooperative manner (iii). Then it enters the nucleus and inhibits the transcriptional activity of the activator, A (iv).

Credit

Professor Jae Kyoung Kim, KAIST

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