Figure 3 (IMAGE)

The University of Osaka

Figure 3

Caption

Single-molecule imaging analysis of the interaction between PTEN and the plasma membrane.

(left) A total internal reflection fluorescence microscopy (TIRFM) image of the living Dictyostelium discoideum cell expressing PTEN labeled with TMR. White spots represent single PTEN molecules bound to the plasma membrane at the bottom of the cell. (right) Trajectories of representative single PTEN molecules on the membrane. When bound to the high-PIP3 membrane, PTEN exhibited a shorter lifetime of membrane interaction and faster lateral diffusion than when bound to the low-PIP3 membrane.

Credit

Masahiro Ueda, Osaka University

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