Figure 2 (IMAGE)
Caption
Mutual inhibition between PIP3 and PTEN.
The reciprocal enrichment of PIP3 and PTEN on the plasma membrane of Dictyostelium discoideum cells upon a gradual decrease in the inhibitor concentration against PI3K, a PIP3-producing enzyme. (upper) Under low-PI3K-activity conditions, PIP3 was not enriched on the plasma membrane. Under moderate-activity conditions, PIP3 abruptly became enriched in response to a slight increase in PI3K activity. Under the high-PI3K-activity conditions, PIP3 was enriched on the membrane. PTEN exhibited a mirrored response to PIP3 toward the gradual increase in PI3K activity. (lower) PIP3-depleted/PTEN-enriched state was adopted over almost all of the membrane under the lowest-activity conditions, while the state was changed to PIP3-enriched/PTEN-depleted state everywhere under the highest conditions.
Credit
Masahiro Ueda, Osaka University
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