3-D Representation from TB Tubercle (IMAGE)

University of Washington

3-D Representation from TB Tubercle

Caption

This is a 3-D representation of a zebra fish TB tubercle mounted and stained to show MMP9 (green) and macrophages (red). Detailed microscopy of the MMP9-producing cells showed that they are epithelial cells surrounding the TB infected macrophages. This image is from a study that suggests that epithelial cells are not bystanders, but are co-opted by the TB bacteria to produce MMP9 and to play a central role in forming tubercles that then benefit the TB bacteria.

Credit

J.M. Davis and T. Pozos

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