Figure 3 (IMAGE)
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(a) Assembly of artificial organelles for energy generation. ATP synthase was reconstituted into CEx-GOx and bo3 oxidase was reconstituted into CEx-HRP. The two CEx were fused and were able to penetrate deep into spheroids. (b) Decrease in pH (-ΔpH) vs. glucose concentrations for different exosomes. Fused exosomes show a greater degree of pH decrease. (c) Changes in ATP production after FEx-1 uptake under different conditions. (d) Artificial organelles were able to penetrate deep into the spheroid. The top row shows FEx-1 (labeled red with rhodamine B), while the bottom row shows free HRP enzyme inside spheroids. (e) Overall ROS levels decreased on subjecting FEx-1 under glucose and DTT.
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Institute for Basic Science
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