Axonal Organelle Transport in Motion (VIDEO)

Technical University of Munich (TUM)

Caption

This movie shows axonal organelle transport in nerve fibers isolated from transgenic mice that express a fluorescent protein in their neuronal mitochondria. The top and bottom are controls (normal, wild type -- WT -- mice and mice overexpressing a non-mutated form of a human ALS-related protein, SOD -- SOD-WT). In the middle are two mouse models of ALS that express two different mutated forms of the human SOD protein (G93A and G85R). As can be seen, there is no clear correlation between the presence of reduced mitochondrial transport (in G93A and SOD-WT) and presence of an ALS-like disease (which both mutations, G93A and G85R, induce).

Credit

Petar Marinkovic;, Misgeld lab, TU Muenchen

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