Nerve-Muscle Synapses in a Mouse Model of ALS (IMAGE)

Technical University of Munich (TUM)

Nerve-Muscle Synapses in a Mouse Model of ALS

Caption

This is a microscopic image of two nerve-muscle synapses in a mouse model of a human motor neuron disease (amyotrophic lateral sclerosis, ALS) in which nerve-muscle contacts break. Energy-producing organelles (mitochondria) were labeled using a fluorescent protein from jellyfish (cyan), while nerve processes are seen as black-grey structures. The nerve-muscle contacts are labeled in red. The upper contact is broken (the black nerve processes have largely lost contact), while the lower looks intact.

Credit

Misgeld lab, TU Muenchen

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