Model of Human ORC (IMAGE)

Cold Spring Harbor Laboratory

Model of Human ORC

Caption

The Origin of Replication Complex (ORC) is a structure that binds to DNA and starts the genome duplication process as a cell gets ready to divide. In this model of human ORC, the almost donut-shaped complex clamps down on DNA (the twisted helix shown in red in the central model). The model on the left shows the complex covered, protecting the DNA binding cavity. The model on the right shows the complex open, empty of DNA.

Credit

Joshua-Tor lab/CSHL, 2020

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