An Array of Human Origin of Replication Complexes (IMAGE)
Caption
An array of human Origin of Replication Complexes (ORCs) in different orientations. The imaging process starts by pouring a solution of complexes onto a tiny gold platform, like thousands of multifaceted dice rolled onto a table. The complexes are frozen in place, in ways that preserve their fine details. Photos of thousands of these complexes, which look like gray silhouettes, are collected. The computer organizes the complexes into shapes that resemble one another, stacking one similar blob atop another, averaging the image, until features start to emerge. Collect enough of these blobs and the computer can divide the stacks into smaller stacks where the angles are slightly different and even finer details emerge.
Credit
Joshua-Tor lab/CSHL, 2020
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