The Proposed Mechanism of Adipose Tissue Aging (IMAGE)

The University of Osaka

The Proposed Mechanism of Adipose Tissue Aging

Caption

Rubicon in adipose tissue reduces with age, resulting in excess autophagy. Excessive autophagy degrades PPARγ coactivators SRC-1 and TIF2, causing a decline in PPARγ activity and adipocyte function and the onset of lifestyle diseases.

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Osaka University

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