Fig. 2 (IMAGE) Shinshu University Caption In wild-type mice, cell survival is maintained by the autocrine action of neurotrophic factors released from the axons of cerebellar granule cells. In wild-type mice, neurexin binds to Cbln1-GluD2 and induces cerebellar synaptogenesis. Granule cells deficient in all neurexins 1, 2, and 3 have abnormal neurotrophic factor release mechanisms, resulting in induced programmed cell death. Credit Takeshi Uemura, Shinshu University Usage Restrictions Credit must be given to the creator. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.