video: Stimulating P2Y11 receptors with an activating compound resulted in rounded cell shapes and the progressive loss of mitochondrial activity throughout the T cells. This material relates to a paper that appeared in the Sep. 29, 2020, issue of Science Signaling, published by AAAS. The paper, by C. Ledderose at Beth Israel Deaconess Medical Center in Boston, MA; and colleagues was titled, "The purinergic receptor P2Y11 choreographs the polarization, mitochondrial metabolism, and migration of T lymphocytes." view more
Credit: [Credit: C. Ledderose <i>et al., Science Signaling</i> (2020)]