News Release

从癌症周围的成纤维细胞分泌物质中,阐明胃癌难治性机制

Peer-Reviewed Publication

Kumamoto University

Annexin A6 is Specific to CAFs

image: <p>A: The expression level of Annexin A6 protein in gastric cancer cells and CAFs. Annexin A6 is expressed only in CAFs. </p> <p>B: Fluorescent immunostaining in tissues from gastric cancer patients. AnnexinA6 (green) is consistently expressed in cancer-associated fibroblasts (CAFs: upper red) (yellow region in merged figure). However, it is rarely expressed in cancer cells (lower red) (yellow areas are barely visible when merged). </p> view more 

Credit: Dr. Takatsugu Ishimoto

  日本熊本大学国际尖端医学研究机构(IRCMS)消化器官癌症生物学的内原智幸研究员,石本崇胤副教授和生命科学研究部消化器官外科学的马场秀夫教授等人组成的研究小组和日本国立癌症研究中心研究所,大阪市立大学,新加坡国立大学和德克萨斯大学MD安德森癌症中心的共同研究表明,癌症相关成纤维细胞(CAFs)※1分泌的细胞外囊泡(EVs)※2中含有的膜联蛋白A6被胃癌细胞吸收后,产生了对抗癌药物治疗的抵抗性。由此发现了针对膜联蛋白A6和癌症相关成纤维细胞(CAFs)的新药开发的可能性。

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该研究成果于2020年6月30日在美国学术期刊《Cancer Research》公开发行。

※1癌症相关成纤维细胞(cancer associated fibroblasts: CAFs) 是构筑肿瘤微环境的特殊成纤维细胞(分泌产生组成肿瘤微环境的纤维),分泌与癌细胞的恶性转化有关的各种因子。

※2细胞外囊泡(Extracellular vesicles: EVs) 是指从细胞膜上脱落或者由细胞分泌的双层膜结构的囊泡状小体,携带有细胞来源相关的蛋白质、RNA、脂类、糖质、矿物质等,参与细胞间通讯等过程。


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