Bone-targeted estrogen delivery reverses postmenopausal osteoporosis in mice
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Updates every hour. Last Updated: 18-Dec-2025 14:11 ET (18-Dec-2025 19:11 GMT/UTC)
Postmenopausal osteoporosis is a condition that weakens bones, making them brittle and prone to fracture. Taking the hormone estradiol can reverse these effects, but it may also increase endometrial and uterine cancer risks. Researchers publishing in ACS’ Nano Letters developed a two-layer shell to encapsulate the hormone so it bypasses the uterus and releases only within an osteoporotic bone. Tests of the drug-delivery system showed improved bone density in treated mice without uterine side effects.
Reusable menstrual cups reduce waste and are more cost-effective than single-use pads and tampons. But some people avoid the cups because they require thorough cleaning and are sometimes messy to empty. To solve these problems, researchers coated a commercially available silicone cup in silicone oil and created a plant-based, absorbent tablet. These design adjustments could make menstrual cups safer and easier to use, according to a study published in ACS Applied Materials & Interfaces.
The appearance of a hot sauce or pepper doesn’t reveal whether it’s mild or likely to scorch someone’s taste buds. So, researchers made an artificial tongue to quickly detect spiciness. Inspired by milk’s casein proteins, which bind to capsaicin and relieve the burn of spicy foods, the researchers incorporated milk powder into a gel sensor. The prototype, reported in ACS Sensors, detected capsaicin and pungent-flavored compounds (like those behind garlic’s zing) in various foods.
Brains, spiders, (were)wolves and slimy eyeballs — a collection of creepy research topics that Dr. Frankenstein would appreciate! But unlike the mad scientist’s work, the research detailed below in ACS journals aims to improve human life by developing an alternative to animal testing, on-demand wound care, an edible protective coating for veggies, and informing future retinal health studies.