How cells repair DNA’s protective barrier: a pathway to address a rare genetic disorder characterized by rapid aging in children
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-May-2025 05:08 ET (1-May-2025 09:08 GMT/UTC)
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA. The findings reveal lamin A's unique role and its potential for treating Hutchinson-Gilford Progeria Syndrome, a rare disorder that causes premature aging.
In a study recently published in the journal Nano Letters, published by American Chemical Society, researchers from Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kanazawa, Japan, used frequency-modulated atomic force microscopy to reveal the submolecular structure of microtubule (MT) inner surface and visualize structural defects in the MT lattice, providing valuable insights into the complex dynamic processes that regulate microtubule function.