A groundbreaking new review comprehensively synthesizes the latest developments in next-generation chimeric antigen receptor T cell (CAR-T) therapies, highlighting key preclinical and clinical breakthroughs in the treatment of lymphoma. The article examines barriers to CAR-T efficacy and provides an in-depth analysis of innovative strategies, including multi-specific CAR, T cells redirected for universal cytokine-mediated killing (TRUCKs), switch receptor CAR, safety switch/suicide system, and in vivo CAR-T cells. With a special focus on the role of epigenetics and metabolism in CAR-T cell exhaustion, the review offers valuable insights and future directions for advancing CAR-T immunotherapy.

 Bispecific antibodies (bsAbs) refer to antibodies that bind two different antigens or epitopes simultaneously, which can enhance the targeting of antibodies and the efficacy of cancer treatments. Recent studies indicate that bsAb is a promising first-line or later-line treatment for non-small cell lung cancer (NSCLC) patients and may overcome treatment resistance. This study explores the classification, mechanisms of action and clinical application of bsAbs in the treatment of NSCLC.

Clinical photothermal therapy continues to encounter significant challenges, including systemic toxicity risks associated with intravenous drug administration and inadequate photothermal specificity in the targeted lesion area, particularly concerning the prevention of bone tumor recurrence. To address these issues, this study developed a photothermal functional composite bioceramic scaffold that integrates a Si₃N₄ matrix known for its excellent antibacterial properties, black glass SiOC exhibiting photothermal characteristics, and bone-inductive graphene oxide (GO). A mapping model was established to correlate the properties of the GO/KH570-H/Si₃N₄ precursor slurry with the parameters of the SLA additive manufacturing process. Following sintering at 1300 ℃, a GO/SiOC/Si₃N₄ composite ceramic was successfully obtained. Under irradiation with 808 nm near-infrared light at an intensity of 1 W/cm², the temperature of the leather-coated composite scaffold reached 47.8 ℃ within 10 minutes. This innovative approach presents a promising solution for precise photothermal therapy in postoperative bone tumor repair.