City of Hope opens phase 1 clinical trial aiming to transform rectal cancer into a disease treatable with radiation therapy to avoid potential long-term side effects of surgery. Physician scientists will evaluate an alternative use of an investigational enzyme inhibitor, papaverine, which is hypothesized to prime regions of tumors to be more susceptible to radiation therapy

A Japanese research team has discovered a novel global cooperative phenomena of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network. The framework they used in their studies could prove useful for investigating the hidden state of a group of cells.

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent reactive oxygen species (ROS), differs from other cell death forms in its immunogenicity. It involves the regulation of the cystine/glutamate transport system xc−, with glutathione (GSH) and glutathione peroxidase 4 (GPX4) preventing toxic lipid peroxide accumulation. Ferroptosis-related factors are implicated in various diseases, including cancer and cardiovascular diseases.