A nanoparticle therapy developed by investigators at University Hospitals (UH) and Case Western Reserve University targets overactive neutrophils, a specific kind of white blood cell, to prevent almost all types of blood clots while causing no increased risk for bleeding. The preclinical findings, published in Science Translational Medicine, may lead to safer ways to care for patients impacted by blood clots. According to the Centers for Disease Control and Prevention (CDC), roughly 900,000 people in the U.S. suffer from life-threatening blood clots each year.
- Science Translational Medicine
For an adequate immune response, it is essential that T lymphocytes recognise infected or degenerated cells. They do so by means of antigenic peptides, which these cells present with the help of specialised surface molecules (MHC I molecules). Using X-ray structure analysis, a research team from Frankfurt has now been able to show how the MHC I molecules are loaded with peptides and how suitable peptides are selected for this purpose.
A research group from Nagoya University has successfully developed a surgical training model using konjac, a processed jelly made from the bulb of the konjac plant. The group’s training model is a type of tissue-mimicking phantom, which physicians can use to practice fluorescence-guided surgery, an important technique in cancer treatment.
- Laryngoscope Investigative Otolaryngology
Cancer shown to affect body image and sexual desire in young women
- Acta Oncologica
- Barncancerfonden, Cancerfonden, FORTE, Karolinska Institutet, Klarman Cell Observatory, Broad Institute, The Vårdal Foundation, the Swedish Cancer Society, the Swedish Childhood Cancer Foundation, the Cancer Research Funds of Radiumhemmet, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Research Council, Radiumhemmets Forskningsfonder, Vetenskapsrådet, Vårdalstiftelsen
Study shows how certain cancers neutralize T cells to subvert the immune system and help tumors grow
Scientists have discovered that cancer exploits the body’s tissue repair process to spread cells around the body. They found that a protein called NALCN is involved in regulating both tissue repair and metastasis. Targeting NALCN with drugs could one day allow us to prevent cancer spread.
- Nature Genetics
- Cancer Research UK, Cancer Research UK Cambridge Institute
An international team of scientists, co-led by researchers at the University of California San Diego School of Medicine, has created the first pan-cancer mycobiome atlas — a survey of 35 types of cancer and their associated fungi.
About The Study: This analysis shows that in the first 10 months of the COVID-19 pandemic, 16,561 deaths occurred in the U.S. among patients with cancer with complications of COVID-19, and were more likely to occur in older patients, minority race and ethnicity groups, and in large metropolitan areas.
- JAMA Oncology
High tumor mutational burden—the number of mutations found inside cancer cells—may not generalize as an accurate biomarker across diverse cancer patient populations, researchers report on September 29 in the journal Cancer Cell. The results could have important implications for clinical decision-making regarding treatment with immune checkpoint inhibitors (ICIs), a type of immunotherapy.
- Cancer Cell
- The Louis B. Mayer Foundation, Doris Duke Charitable Foundation, Phi Beta Psi Sorority, Emerson Collective, Dana-Farber Trustee Science Committee Fellowship