Higher levels of a key inflammatory marker were related to older breast cancer survivors reporting cognitive problems, researchers found in one of the first long-term efforts to examine the potential link between chronic inflammation and cognition in older breast cancer survivors.

A nanoparticle therapy developed by investigators at University Hospitals (UH) and Case Western Reserve University targets overactive neutrophils, a specific kind of white blood cell, to prevent almost all types of blood clots while causing no increased risk for bleeding. The preclinical findings, published in Science Translational Medicine, may lead to safer ways to care for patients impacted by blood clots. According to the Centers for Disease Control and Prevention (CDC), roughly 900,000 people in the U.S. suffer from life-threatening blood clots each year.

For an adequate immune response, it is essential that T lymphocytes recognise infected or degenerated cells. They do so by means of antigenic peptides, which these cells present with the help of specialised surface molecules (MHC I molecules). Using X-ray structure analysis, a research team from Frankfurt has now been able to show how the MHC I molecules are loaded with peptides and how suitable peptides are selected for this purpose.

Cancer shown to affect body image and sexual desire in young women

About The Study: This analysis shows that in the first 10 months of the COVID-19 pandemic, 16,561 deaths occurred in the U.S. among patients with cancer with complications of COVID-19, and were more likely to occur in older patients, minority race and ethnicity groups, and in large metropolitan areas.

High tumor mutational burden—the number of mutations found inside cancer cells—may not generalize as an accurate biomarker across diverse cancer patient populations, researchers report on September 29 in the journal Cancer Cell. The results could have important implications for clinical decision-making regarding treatment with immune checkpoint inhibitors (ICIs), a type of immunotherapy.