Cancer's double agents: Fibroblasts both help and hinder immunotherapy
Peer-Reviewed Publication
Updates every hour. Last Updated: 1-Aug-2025 03:11 ET (1-Aug-2025 07:11 GMT/UTC)
Cancer-associated fibroblasts (CAFs) create immune-dampening environments that help tumors grow, yet paradoxically, specific CAF subtypes can boost anti-tumor immunity. This review reveals how CAF heterogeneity explains conflicting immunotherapy outcomes and proposes precision strategies to target "bad" CAFs while preserving beneficial ones.
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