A case report describes a 75-year-old woman with advanced colon cancer who developed widespread papules and nodules on the face and neck after oral capecitabine. Genetic and histopathological findings supported capecitabine-induced eruptive keratoacanthoma. The authors warn that without clinical context these lesions can be mistaken for squamous cell carcinoma and should be considered in similar patients with advanced cancer.

Precisely applying light to a gelatin-based hydrogel — an engineered scaffolding that supports cells — enables exact directional and morphological control of cellular growth, according to a new study led by researchers at YOKOHAMA National University. The finding may not only help advance engineered biological tissue, the researchers said, but also elucidate how cancer cells form and migrate in the body.

- KAIST and THOR Therapeutics block a signal that causes appetite loss and excessive energy expenditure in cancer cachexia

- In cachexia mice model, the antibody restored body weight and food intake, reduced muscle and fat loss, and improved grip strength by about 30% compared with the control group

- The team identified how the antibody works and improved its production efficiency and stability, with plans to develop a therapy that helps cancer patients maintain their physical strength

Australian researchers map, in unprecedented detail, the immune cells through which genetic differences between people influence disease. The researchers analysed the gene sequence and activity of more than 5 million individual immune cells from nearly 2,000 people, the largest dataset of its kind in the world. The findings open a path to precision medicine for diseases ranging from autoimmune conditions like multiple sclerosis to neurological conditions such as Alzheimer’s and cancers including breast and prostate.