In a review published in Molecular Biomedicine, a team of Chinese scientists summarizes the pivotal role of N⁶-methyladenosine (m⁶A)—the most abundant chemical modification in eukaryotic mRNA—in cancer biology. The authors describe how m⁶A regulators (writers, erasers, and readers) influence tumor progression, metastasis, treatment resistance, and the tumor microenvironment. They also discuss emerging therapeutic strategies, including small-molecule inhibitors, RNA-based editing technologies, and combination therapies, highlighting m⁶A's potential as a diagnostic and prognostic biomarker and a target for precision oncology.

In a comprehensive review published in MedComm - Oncology, a research team sheds new light on the complex biology and therapeutic challenges of breast cancer brain metastasis (BCBrM). The authors detail the multi-step metastatic cascade, from primary tumor invasion to brain colonization, and highlight key signaling pathways such as TGF-β, Wnt/β-catenin, PI3K/AKT, Notch, HER2-HER3, and JAK/STAT. They also explore the dynamic interactions between tumor cells and the brain microenvironment, including astrocytes, microglia, and neurons, which facilitate immune evasion and metabolic adaptation. The review further discusses advances in preclinical models, emerging CNS-penetrant therapies, and innovative clinical trial designs, offering a roadmap for personalized management of BCBrM.

People living with HIV who smoke are more likely to die from lung cancer than HIV. With more than $3 million from the National Heart, Lung and Blood Institute, Hollings Cancer Center researchers at the Medical University of South Carolina will seek to improve access to evidence-based tobacco cessation treatments for people living with HIV by training pharmacists at six Ryan White clinics in South Carolina as tobacoo treatment specialists and working with them to develop processes to ensure lasting success of the program.

BUFFALO, NY — October 30, 2025 — A new case report was published in Volume 12 of Oncoscience on October 9, 2025, titled “Vulvar mucinous cyst mimicking common lesions with concurrent multiple bartholin cysts in a reproductive-age woman: A rare case report and review of literature.”

Despite clear evidence linking alcohol use to increased cancer risks, public awareness of this connection remains low in the U.S., according to new research from The University of Texas MD Anderson Cancer Center. Researchers found that more than half of American adults (52.9%) did not know alcohol affects cancer risk.