FDA approves drug for patients with HR+, HER2+ advanced breast cancer based on results from alliance foundation trials PATINA trial
Business Announcement
Updates every hour. Last Updated: 25-Jun-2026 10:16 ET (25-Jun-2026 14:16 GMT/UTC)
Today, Alliance Foundation Trials, LLC (AFT) was informed that the U.S. Food and Drug Administration has approved palbociclib in combination with trastuzumab, with or without pertuzumab, and endocrine therapy for adult patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–positive (HER2+) locally advanced or metastatic breast cancer following induction treatment. This marks a major milestone and offers new hope for individuals living with this challenging subtype of advanced breast cancer.
Researchers from EMBL, LUMC, and collaborators reanalysed nearly 6,800 gut microbiome profiles in colorectal cancer patients and controls.
One of the largest single-disease gut microbiome meta-analyses to date, the new study identified a robust colorectal cancer microbiome signature that was consistent across populations, sequencing methods, and age-of-onset groups.
A machine-learning classifier could distinguish colorectal cancer from non-cancer microbiomes across datasets.
The colorectal cancer microbiome signature was linked to lower dietary fibre intake and could be reduced through fibre-focused dietary interventions.
A new Houston Methodist study highlights a promising noninvasive imaging technique that could help doctors more accurately diagnose papillary thyroid cancer, the most common type of thyroid cancer.
New research among lung cancer screening participants has found that low-dose chest computed tomography (CT) screening is generally well tolerated both physically and emotionally, but experiences vary across socioeconomic groups. Lower-income and safety-net participants experienced higher testing-related burden, with factors such as insurance and employment status associated with more discomfort or anxiety. The findings in the Journal of the American College of Radiology, published by Elsevier, highlight opportunities to improve equity in screening.
Michigan State University researchers have identified how ovarian cancer cells become resistant to chemotherapy and discovered a protein, that, when blocked, can restore the drug’s effectiveness.